Using Polygenic Scores to Guide Beta-blocker Therapy for Heart Failure With Mildly Reduced Ejection Fraction
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systolic volume index by MRI.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 89
Healthy Volunteers: f
View:
• Age 18-89 years
• Ejection Fraction (EF) \>40% and =\<50% by any modality within 1 year (must be most recent)
• Clinical diagnosis of HF within 1 year, evidenced by any one: Hospital discharge with primary or secondary HF diagnosis, ER discharge with primary diagnosis of HF, ambulatory diagnostic code for HF and diuretic use, BNP\>35 ng/L or NTproBNP \>125 ng/L at any time
Locations
United States
Michigan
Henry Ford Health
RECRUITING
Detroit
Contact Information
Primary
Whitney Cabral, MS
wcabral1@hfhs.org
313-949-6616
Time Frame
Start Date: 2025-09
Estimated Completion Date: 2026-08
Participants
Target number of participants: 10
Treatments
Experimental: Beta Blocker
This group will be dispensed and titrated on beta blocker according to study protocol.
No_intervention: Placebo
This group will be dispensed and titrated on placebo according to study protocol.
Related Therapeutic Areas
Sponsors
Leads: David Lanfear